The current pandemic coincides with an exceptional and challenging time for Southeast Asia as its countries try to navigate difficult internal conditions, major geopolitical shifts, and international trade tensions. The challenges appear to be many for the future of responsible business in the region where the corporate sector have been already lagging behind societal demands for responsibility. This panel discussion examines how governments, businesses, industry associations, civil society organizations, and business and human rights stakeholders can respond to the challenges facing responsible business, and what will be needed to prepare for the changes that lie ahead in efforts to tackle societal problems like climate change, and the impacts of business activities on individuals and societies.