While large users of medicines such as medical facilities and veterinary clinics are one of the major sources for drug resistant bacteria, it should not be forgotten that marine environments also contain areas that serve as hotspots for drug resistant bacteria. One of these are mariculture sites. Mariculture sites that make use of antimicrobial agents and antibiotics are sources for drug resistant bacteria, but at the same time are points of contact between the ocean and humans. This article discusses the current and future states of drug resistant bacteria in aquatic environments, with a focus on mariculture environments, which can also serve as an environmental risk factor.