From the late Edo period, there were frequent cholera outbreaks in Japan against the background of trade with foreign countries. In the fall of 1877 (Meiji 10), outbreaks were reaching nation-wide levels due to soldiers with cholera returning from the Satsuma Rebellion. In response to the spread, the Meiji government, unable to suppress the spread at the border, focused their efforts on establishing quarantine laws. I would like to introduce how there were also various trials and errors involved in the history of border quarantines.